Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 14/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3205594 | 0.74 | CHRM2 (0.41) | KCNH2MAPT | |
| SCHEMBL5656515 | 0.74 | KCNH2 (0.44) | KCNH2HTTSLC2A1 | |
| SCHEMBL3504744 | 0.71 | KDM2B (0.30) | — | |
| SCHEMBL5748093 | 0.70 | ALDH1A1 (0.38) | KCNH2HTTKDM4EALDH1A1LMNA | |
| SCHEMBL5439117 | 0.69 | PTGS1 (0.36) | KCNH2GAAKDM4EALDH1A1LMNA | |
| SCHEMBL2076961 | 0.69 | MAPK1 (0.37) | GAAHTTKDM4EALDH1A1LMNA | |
| SCHEMBL15191890 | 0.69 | KCNJ1 (0.49) | KCNH2 | |
| SCHEMBL3009489 | 0.69 | CYP2J2 (0.32) | KCNH2LMNA | |
| SCHEMBL21820340 | 0.68 | P2RX7 (0.32) | — | |
| SCHEMBL3572416 | 0.68 | ALOX15 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136807-B1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE DERIVATIVES FOR TREATING TUBERCULOSIS | GLAXO GROUP LTD (GB) | 2010-11-03 | — | — | EP | disclosed |