Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395858 | 0.86 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1HPGDLMNASMN1; SMN2 | |
| SCHEMBL3396153 | 0.86 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1HPGDKDM4EYTHDC1 | |
| SCHEMBL3396083 | 0.83 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1HPGDDAPK1FLT4 | |
| SCHEMBL3393558 | 0.81 | HSP90AB1 (0.77) | HSP90AA1HSP90AB1 | |
| 9-Benzyl-6-Methoxy-9H-Purine SCHEMBL28939425 | 0.80 | HPGD (0.77) | HPGDDAPK1FLT4KDRKDM4E | |
| SCHEMBL5458555 | 0.77 | ADORA2A (0.52) | HSP90AA1HSP90AB1 | |
| SCHEMBL28939424 | 0.77 | HPGD (0.59) | HPGDDAPK1FLT4KDRMEN1 | |
| SCHEMBL3393884 | 0.76 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1HPGDDAPK1FLT4 | |
| SCHEMBL17364335 | 0.75 | ADORA2A (0.60) | HPGDDAPK1FLT4KDRMEN1 | |
| SCHEMBL22533420 | 0.74 | HPGD (0.56) | HPGDDAPK1FLT4KDRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145888-A1 | Deazapurine derivatives as HSP90-Inhibitors | Conforma Therapeutics Corporation (US) | 2010-01-20 | — | — | EP | disclosed |
| EP-1670802-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS | Conforma Therapeutic Corporation (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005028434-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS | CONFORMA THERAPEUTICS CORPORATION (US) | 2005-03-31 | — | — | WO | disclosed |