Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.69 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 9/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11827194 | 0.86 | HDAC6 (0.54) | HSP90AA1HSP90AB1FGFR1FGFR4HDAC6 | |
| SCHEMBL3395811 | 0.86 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1YTHDC1HPGDKDM4E | |
| SCHEMBL3395858 | 0.85 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1HPGDLMNASMN1; SMN2 | |
| SCHEMBL5462823 | 0.82 | HDAC6 (0.53) | HSP90AA1HSP90AB1FGFR1FGFR4HDAC6 | |
| SCHEMBL3393012 | 0.81 | HSP90AB1 (1.00) | HSP90AA1HSP90AB1HDAC6 | |
| SCHEMBL5465357 | 0.80 | HPGD (0.64) | FGFR1FGFR4HDAC6HPGDMEN1 | |
| SCHEMBL5458724 | 0.78 | YTHDC1 (0.61) | FGFR1FGFR4HDAC6YTHDC1HPGD | |
| SCHEMBL3812963 | 0.77 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1YTHDC1KDM4EMEN1 | |
| SCHEMBL5458555 | 0.76 | ADORA2A (0.52) | HSP90AA1HSP90AB1 | |
| SCHEMBL3391524 | 0.76 | HSP90AB1 (0.69) | HSP90AA1HSP90AB1HDAC6YTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145888-A1 | Deazapurine derivatives as HSP90-Inhibitors | Conforma Therapeutics Corporation (US) | 2010-01-20 | — | — | EP | disclosed |
| US-20070203159-A1 | Purine compounds | UNIVERSITETET I OLSO (NO) | 2007-08-30 | — | — | US | disclosed |
| EP-1670802-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS | Conforma Therapeutic Corporation (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005028434-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS | CONFORMA THERAPEUTICS CORPORATION (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203159-A1 | Purine compounds | PNP, UMPS, TYMP | HSP90AA1 4068/4885HSP90AB1 3579/4885FGFR1 3760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.