Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 10/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CLK2 | P49760 | 2/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392201 | 0.79 | SLC6A4 (0.38) | LMNAHDAC6MEN1KMT2A | |
| SCHEMBL14562861 | 0.72 | SERPINE1 (0.53) | PPARAMEN1KMT2A | |
| SCHEMBL5538015 | 0.70 | LSS (0.51) | PDK1MEN1KMT2A | |
| SCHEMBL27629442 | 0.70 | EPHX1 (0.50) | PDK1MEN1KMT2A | |
| SCHEMBL3423840 | 0.69 | SLC6A4 (0.50) | — | |
| SCHEMBL13070333 | 0.69 | SLC6A4 (0.50) | — | |
| SCHEMBL15697592 | 0.69 | CLK1 (0.57) | CLK1DYRK1ACLK2DYRK1BCLK4 | |
| SCHEMBL30805945 | 0.69 | CLK1 (0.57) | CLK1DYRK1ACLK2DYRK1BCLK4 | |
| SCHEMBL18003474 | 0.69 | PTPN2 (0.54) | CLK1DYRK1ACLK2DYRK1BPPARA | |
| SCHEMBL2947888 | 0.69 | LMNA (0.60) | CLK1DYRK1ALMNADYRK1BL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |