Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3397309 | 0.84 | SLC6A4 (0.36) | SLC6A4PRMT6HDAC6PIM1PIM2 | |
| SCHEMBL3423840 | 0.80 | SLC6A4 (0.50) | SLC6A4PRMT6SLC6A3ALDH1A1TSHR | |
| SCHEMBL13070333 | 0.80 | SLC6A4 (0.50) | SLC6A4PRMT6SLC6A3ALDH1A1TSHR | |
| SCHEMBL3396182 | 0.79 | CLK1 (0.57) | HDAC6LMNAMEN1KMT2A | |
| SCHEMBL3392203 | 0.76 | SCN8A (0.40) | HDAC6HSP90AA1 | |
| SCHEMBL3396194 | 0.76 | PRMT6 (0.40) | SLC6A4PRMT6HDAC6SLC6A3ALDH1A1 | |
| SCHEMBL13074386 | 0.75 | SLC6A4 (0.57) | SLC6A4PRMT6SLC6A3ALDH1A1TSHR | |
| SCHEMBL3708151 | 0.75 | PIM1 (0.39) | PRMT6HDAC6PIM1PIM2 | |
| Hydrochloric Acid SCHEMBL3394496 | 0.74 | PIM1 (0.38) | PRMT6HDAC6PIM1PIM2 | |
| SCHEMBL12777905 | 0.69 | NPC1 (0.43) | HDAC6LMNAPIM1KMT2ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |