Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.62 |
| ▸ | DRD2 | P14416 | 8/20 | 0.62 |
| ▸ | HTR2A | P28223 | 3/20 | 0.62 |
| ▸ | HTR7 | P34969 | 3/20 | 0.62 |
| ▸ | HTR6 | P50406 | 3/20 | 0.62 |
| ▸ | DRD3 | P35462 | 4/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26880831 | 0.89 | DRD2 (0.67) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL11679210 | 0.85 | LMNA (0.66) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL11676934 | 0.84 | HTR1A (0.68) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL11676714 | 0.84 | HTR1A (0.64) | HTR1ADRD2HTR2AHTR7HTR6 | |
| Hydrochloric Acid SCHEMBL11677902 | 0.83 | SMN1; SMN2 (0.63) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL253679 | 0.81 | DRD2 (0.67) | HTR1ADRD2HTR7DRD3ADRA1A | |
| SCHEMBL8131826 | 0.80 | HTR1A (0.65) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL16633469 | 0.80 | DRD2 (0.59) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL3411899 | 0.80 | SLC6A2 (0.76) | HTR1ADRD2DRD3ADRA1AMAPT | |
| SCHEMBL8130173 | 0.80 | DRD2 (0.71) | HTR1ADRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003418-A2 | FUNCTIONALLY SELECTIVE LIGANDS OF DOPAMINE D2 RECEPTORS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-01-05 | — | — | WO | disclosed |