Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | CDC25C | P30307 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9628028 | 0.84 | KCNH2 (0.74) | KCNH2SIGMAR1CDC25CTSHRMEN1 | |
| SCHEMBL9628754 | 0.80 | KCNH2 (0.65) | KCNH2SIGMAR1CDC25CTSHRMEN1 | |
| SCHEMBL3143117 | 0.80 | KCNH2 (0.64) | KCNH2SIGMAR1CDC25CTSHRMEN1 | |
| SCHEMBL13897015 | 0.78 | KCNH2 (0.72) | KCNH2SIGMAR1CDC25CTSHRMEN1 | |
| SCHEMBL777298 | 0.77 | KCNH2 (0.60) | KCNH2SIGMAR1CDC25CTSHRPYCR1 | |
| SCHEMBL2479710 | 0.77 | TSHR (0.54) | KCNH2SIGMAR1CDC25CTSHRMEN1 | |
| SCHEMBL9628784 | 0.77 | KCNH2 (0.57) | KCNH2SIGMAR1CDC25CTSHRMEN1 | |
| Hydrochloric Acid SCHEMBL9628308 | 0.76 | SIGMAR1 (0.64) | KCNH2SIGMAR1CDC25CTSHRMEN1 | |
| SCHEMBL7596877 | 0.75 | ALDH1A1 (0.63) | KCNH2SIGMAR1CDC25CMEN1THRB | |
| SCHEMBL3149347 | 0.75 | ALDH1A1 (0.63) | KCNH2SIGMAR1CDC25CMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015703-A2 | NOVEL 6-O-SUBSTITUTED 15-MEMBERED 8A- AND 9A-LACTAMS | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2010-02-11 | — | — | WO | disclosed |