Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 10/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398614 | 0.86 | CACNA1B (0.62) | CACNA1BCACNA1HLMNAHTTSMN1; SMN2 | |
| SCHEMBL7163236 | 0.83 | LMNA (0.54) | LSSCACNA1BCACNA1HLMNAHTT | |
| SCHEMBL3363582 | 0.81 | LSS (0.56) | LSSCACNA1BCACNA1HALDH1A1 | |
| SCHEMBL3364647 | 0.80 | LSS (0.57) | LSSCACNA1BCACNA1HALDH1A1 | |
| SCHEMBL3368283 | 0.80 | LSS (0.56) | LSS | |
| SCHEMBL3363347 | 0.79 | LSS (0.57) | LSS | |
| SCHEMBL7169288 | 0.78 | CYP19A1 (0.53) | CACNA1BCACNA1HLMNAHTTSMN1; SMN2 | |
| SCHEMBL3399092 | 0.78 | LSS (0.52) | LSSCACNA1BCACNA1HLMNAHTT | |
| SCHEMBL3365436 | 0.76 | CACNA1B (0.48) | LSSCACNA1BCACNA1H | |
| SCHEMBL3399066 | 0.74 | SMN1; SMN2 (0.53) | LSSCACNA1BCACNA1HLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303503-B1 | ANILINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | claimed |