Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 7/20 | 0.62 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.48 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7163236 | 0.88 | LMNA (0.54) | CACNA1BCACNA1HHTTLMNASMN1; SMN2 | |
| SCHEMBL3397097 | 0.86 | LSS (0.51) | CACNA1BCACNA1HHTTLMNASMN1; SMN2 | |
| SCHEMBL7169288 | 0.85 | CYP19A1 (0.53) | CACNA1BCACNA1HHTTLMNASMN1; SMN2 | |
| SCHEMBL3399092 | 0.85 | LSS (0.52) | CACNA1BCACNA1HHTTLMNASMN1; SMN2 | |
| SCHEMBL3365294 | 0.83 | CACNA1B (0.87) | CACNA1BCACNA1HLMNASMN1; SMN2 | |
| SCHEMBL3366991 | 0.79 | CACNA1B (0.60) | CACNA1BCACNA1HSMN1; SMN2ALDH1A1 | |
| SCHEMBL3365881 | 0.77 | CACNA1B (0.61) | CACNA1BCACNA1HSMN1; SMN2ALDH1A1 | |
| SCHEMBL3399066 | 0.77 | SMN1; SMN2 (0.53) | CACNA1BCACNA1HHTTLMNASMN1; SMN2 | |
| SCHEMBL13959213 | 0.75 | CYP19A1 (0.63) | HTTLMNASMN1; SMN2CYP19A1ALDH1A1 | |
| SCHEMBL3365343 | 0.75 | CACNA1B (0.55) | CACNA1BCACNA1HSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303503-B1 | ANILINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | disclosed |