SCHEMBL7169288

SCHEMBL7169288

O=S(=O)(NCc1ccc(OCCCCCCBr)cc1)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.53
LMNA P02545 3/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
HTT P42858 2/20 0.52
TSHR P16473 2/20 0.52
SCN3A Q9NY46 1/20 0.51
ALDH1A1 P00352 4/20 0.47
NR2F2 P24468 1/20 0.47
RAB9A P51151 1/20 0.47
CACNA1H O95180 2/20 0.47
CACNA1B Q00975 2/20 0.47
NAMPT P43490 2/20 0.47
AR P10275 1/20 0.46
HRH3 Q9Y5N1 3/20 0.44
KCNH2 Q12809 1/20 0.44
HDAC3 O15379 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3398614 0.85 CACNA1B (0.62) CYP19A1LMNASMN1; SMN2HTTTSHR
SCHEMBL7163236 0.84 LMNA (0.54) CYP19A1LMNASMN1; SMN2HTTTSHR
SCHEMBL3399092 0.82 LSS (0.52) CYP19A1LMNASMN1; SMN2HTTTSHR
SCHEMBL4104367 0.79 NOS1 (0.52)
SCHEMBL17233207 0.79 NOS1 (0.52)
SCHEMBL31706291 0.79 NOS1 (0.52)
SCHEMBL6750419 0.79 NOS1 (0.52)
SCHEMBL3397097 0.78 LSS (0.51) CYP19A1LMNASMN1; SMN2HTTTSHR
SCHEMBL7248303 0.78 NOS1 (0.51) ALDH1A1
SCHEMBL7983880 0.75 CYP19A1 (0.76) CYP19A1LMNASMN1; SMN2HTTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1303503-A2 ANILINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2003-04-23 EP disclosed
WO-2002006189-A2 ANILINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2002-01-24 WO disclosed