Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 15/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2302270 | 0.81 | GCGR (0.33) | MAPK14GCGRMET | |
| SCHEMBL2300003 | 0.81 | GCGR (0.33) | MAPK14GCGRMET | |
| SCHEMBL2356663 | 0.73 | MET (0.34) | TGFBR1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2298510 | 0.73 | MET (0.34) | TGFBR1MAPK14GCGRMET | |
| SCHEMBL2301072 | 0.73 | TGFBR1 (0.34) | TGFBR1MAPK14MET | |
| SCHEMBL2299259 | 0.72 | TGFBR1 (0.34) | TGFBR1GCGRTGFBR2MET | |
| SCHEMBL16503263 | 0.72 | TGFBR1 (0.34) | TGFBR1GCGRTGFBR2MET | |
| SCHEMBL2298547 | 0.71 | GCGR (0.34) | TGFBR1GCGRMET | |
| SCHEMBL2297839 | 0.70 | ACLY (0.37) | MAPK14GCGRMET | |
| SCHEMBL2301664 | 0.68 | TGFBR1 (0.35) | TGFBR1GCGRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2244711-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Incorporated (US) | 2010-11-03 | — | — | EP | claimed |
| WO-2009099594-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-08-13 | — | — | WO | claimed |