Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4296929 | 0.92 | L3MBTL1 (0.51) | L3MBTL1RORCKDM4EHRH3ALDH1A1 | |
| SCHEMBL4048591 | 0.86 | KDM4E (0.55) | L3MBTL1KDM4EALDH1A1GAAMEN1 | |
| SCHEMBL3397376 | 0.74 | GFER (0.51) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL4289837 | 0.74 | CHKA (0.55) | KDM4EALDH1A1GAATDP1 | |
| SCHEMBL2106701 | 0.71 | ALDH1A1 (0.46) | KDM4EHRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL17422248 | 0.71 | MEN1 (0.50) | KDM4EALDH1A1MEN1KMT2AALOX15 | |
| SCHEMBL1427472 | 0.70 | ALDH1A1 (0.49) | KDM4EHRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL4287610 | 0.70 | KDM4E (0.39) | KDM4EHRH3ALDH1A1TDP1 | |
| SCHEMBL5539795 | 0.68 | HRH3 (0.53) | L3MBTL1RORCKDM4EHRH3ALDH1A1 | |
| SCHEMBL2574046 | 0.68 | KMT2A (0.42) | KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247591-A1 | PYRROLO [2, 3-D]PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009098236-A1 | PYRROLO [2, 3-D] PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-08-13 | — | — | WO | disclosed |