Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL153020 | 0.91 | SIGMAR1 (0.53) | SIGMAR1TSHRMAOASLC6A4SLC6A3 | |
| SCHEMBL220097 | 0.81 | SIGMAR1 (0.62) | SIGMAR1ALDH1A1TSHRSMN1; SMN2LTA4H | |
| SCHEMBL457139 | 0.80 | SIGMAR1 (1.00) | SIGMAR1POLBLTA4H | |
| SCHEMBL10677264 | 0.80 | SIGMAR1 (1.00) | SIGMAR1POLBLTA4H | |
| SCHEMBL20676401 | 0.79 | SIGMAR1 (0.96) | SIGMAR1POLBLTA4H | |
| Hydrochloric Acid SCHEMBL7554612 | 0.79 | SIGMAR1 (0.96) | SIGMAR1POLBLTA4H | |
| SCHEMBL5174964 | 0.79 | LTA4H (0.53) | LTA4HMAOA | |
| SCHEMBL28187150 | 0.78 | SIGMAR1 (0.81) | SIGMAR1POLBLTA4HMAOA | |
| SCHEMBL28379360 | 0.77 | GAA (0.44) | SIGMAR1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL19439278 | 0.77 | HTR1A (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247590-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | Merz Pharma GmbH & Co. KGaA (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |
| WO-2009095254-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |