Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.40 |
| ▸ | JAK3 | P52333 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276612 | 0.83 | JAK3 (0.55) | SYKJAK3MAPK1CYP2C9 | |
| SCHEMBL3397956 | 0.73 | MAPK1 (0.42) | MAPK1CYP2D6CYP3A4 | |
| SCHEMBL3396270 | 0.73 | CDK8 (0.48) | SYKJAK3MAPK1CYP2D6 | |
| SCHEMBL3398379 | 0.73 | SYK (0.56) | SYKMAPK1CYP2C9MAP4K1 | |
| SCHEMBL3399095 | 0.72 | CDK8 (0.42) | SYKJAK3MAPK1CYP2D6 | |
| SCHEMBL3395308 | 0.71 | MAPK1 (0.34) | SYKJAK3MAPK1CYP2C9 | |
| SCHEMBL3396005 | 0.71 | SCN9A (0.42) | SYKJAK3MAPK1CYP2D6CYP2C9 | |
| SCHEMBL3393845 | 0.70 | MAPK1 (0.38) | SYKJAK3MAPK1CYP2D6 | |
| SCHEMBL3398976 | 0.70 | MAPK1 (0.49) | SYKJAK3MAPK1CYP2D6 | |
| SCHEMBL3400811 | 0.70 | ADK (0.48) | SYKMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | claimed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |