Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | FABP2 | P12104 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL341218 | 0.86 | PPARA (0.38) | PTGS1 | |
| SCHEMBL339362 | 0.82 | CXCL8 (0.46) | CXCL8MAPTLMNAHTTMAPK1 | |
| SCHEMBL340339 | 0.82 | CXCL8 (0.39) | CXCL8MAPTLMNAHTTUSP2 | |
| SCHEMBL339426 | 0.80 | HSP90AA1 (0.34) | CXCL8LMNAHTTMAPK1HSP90AA1 | |
| SCHEMBL16053132 | 0.72 | GABBR2 (0.43) | TSHRCYP1A2 | |
| SCHEMBL338541 | 0.72 | MAPT (0.43) | CXCL8MAPTPTGS2MEN1KMT2A | |
| SCHEMBL341017 | 0.72 | KMT2A (0.45) | CXCL8MAPTLMNAHTTPTGS2 | |
| SCHEMBL341491 | 0.70 | SOAT1 (0.46) | CXCL8MAPTLMNAMEN1KMT2A | |
| SCHEMBL340819 | 0.70 | MAPT (0.39) | CXCL8MAPTLMNAHTTUSP2 | |
| SCHEMBL341020 | 0.68 | POLB (0.41) | MAPTLMNAHTTHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703990-B2 | Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid | Zhejiang Jiuzhous Pharmaceutical Co., Ltd. (CN) | 2014-04-22 | — | — | US | claimed |
| US-9181175-B2 | Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid | Zhejiang Jiuzhous Pharmaceutical Co., Ltd. (CN) | 2015-11-10 | — | — | US | disclosed |
| EP-2387558-B1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2014-08-27 | — | — | EP | disclosed |
| US-20140179947-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2014-06-26 | — | — | US | disclosed |
| US-8703990-B2 | Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid | Zhejiang Jiuzhous Pharmaceutical Co., Ltd. (CN) | 2014-04-22 | — | — | US | disclosed |
| US-20120016151-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | NOVARTIS AG (CH) | 2012-01-19 | — | — | US | disclosed |
| EP-2387558-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | Zhejiang Jiuzhou Pharmaceutical Co., Ltd. (CN) | 2011-11-23 | — | — | EP | disclosed |
| US-20110253230-A1 | Temperature Sensitive Valve Having Shape Memory Actuator | OMNITEK PARTNERS LLC (US) | 2011-10-20 | — | — | US | disclosed |
| WO-2010081410-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179947-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | DNPEP, MME, DPP7 | CXCL8 4581/4885MAPT 1676/4885LMNA 1839/4885 |
| US-20120016151-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | DNPEP, MME, DPP7 | CXCL8 4581/4885MAPT 1676/4885LMNA 1839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.