Sugi Predict

Sugi Predict / Compounds / SCHEMBL339362

SCHEMBL339362

SCHEMBL339362

CC(=O)Nc1c(-c2ccccc2)cccc1C(C)C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CXCL8 P10145 1/20 0.46
▸ HSP90AA1 P07900 2/20 0.46
▸ HSP90AB1 P08238 2/20 0.46
▸ MMP1 P03956 1/20 0.43
▸ MMP2 P08253 1/20 0.43
▸ MMP9 P14780 1/20 0.43
▸ MMP8 P22894 1/20 0.43
▸ MMP12 P39900 1/20 0.43
▸ MMP13 P45452 1/20 0.43
▸ MMP14 P50281 1/20 0.43
▸ MMP16 P51512 1/20 0.43
▸ PTGS2 P35354 4/20 0.42
▸ KMT2A Q03164 4/20 0.41
▸ PTGS1 P23219 3/20 0.41
▸ LMNA P02545 3/20 0.41
▸ MEN1 O00255 3/20 0.41
▸ MAPT P10636 3/20 0.41
▸ CYP1A2 P05177 2/20 0.41
▸ FABP2 P12104 1/20 0.41
▸ TSHR P16473 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL341017 0.87 KMT2A (0.45) CXCL8MMP1MMP2MMP9MMP8
SCHEMBL338541 0.85 MAPT (0.43) CXCL8MMP1MMP2MMP9MMP8
SCHEMBL339798 0.82 CXCL8 (0.34) CXCL8HSP90AA1HSP90AB1PTGS2KMT2A
SCHEMBL341491 0.82 SOAT1 (0.46) CXCL8KMT2ALMNAMEN1MAPT
SCHEMBL341218 0.81 PPARA (0.38) MMP2PTGS1
SCHEMBL341352 0.80 LMNA (0.50) CXCL8HSP90AA1HSP90AB1KMT2ALMNA
SCHEMBL339426 0.80 HSP90AA1 (0.34) CXCL8HSP90AA1HSP90AB1MMP1MMP2
SCHEMBL6326391 0.80 MAOA (0.53) HSP90AA1HSP90AB1LMNACYP1A2CYP2C9
SCHEMBL18061111 0.79 TAAR1 (0.51) KMT2ALMNAMEN1POLBSMN1; SMN2
SCHEMBL2393839 0.79 PTGS2 (0.56) CXCL8MMP1MMP2MMP9MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3359522-B1 PROCESS FOR PREPARATION OF N-BOC BIPHENYL ALANINOL CHIRAL QUEST SUZHOU CO LTD (CN) 2020-02-26 — — EP disclosed
US-10183909-B2 Process for preparation of N-Boc biphenyl alaninol CHIRAL QUEST (SUZHOU) CO., LTD. (CN) 2019-01-22 — — US disclosed
US-20180297941-A1 PROCESS FOR PREPARATION OF N-BOC BIPHENYL ALANINOL CHIRAL QUEST (SUZHOU) CO., LTD. (CN) 2018-10-18 — — US disclosed
EP-2890672-B1 PROCESSES FOR PREPARING INTERMEDIATES FOR THE MANUFACTURE OF NEP INHIBITORS NOVARTIS AG (CH) 2018-05-30 — — EP disclosed
US-9624163-B2 Process for preparing intermediates useful in the manufacture of NEP inhibitors NOVARTIS AG (CH) 2017-04-18 — — US disclosed
WO-2017059759-A1 PROCESS FOR PREPARATION OF N-BOC BIPHENYL ALANINOL CHIRAL QUEST (SUZHOU) CO., LTD. (CN) 2017-04-13 — — WO disclosed
US-9181175-B2 Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid Zhejiang Jiuzhous Pharmaceutical Co., Ltd. (CN) 2015-11-10 — — US disclosed
US-20150210632-A1 NEW PROCESS NOVARTIS AG (CH) 2015-07-30 — — US disclosed
EP-2890672-A1 NEW PROCESS Novartis AG (CH) 2015-07-08 — — EP disclosed
EP-2387558-B1 PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID ZHEJIANG JIUZHOU PHARM CO LTD (CN) 2014-08-27 — — EP disclosed
US-20140179947-A1 PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) 2014-06-26 — — US disclosed
US-8703990-B2 Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid Zhejiang Jiuzhous Pharmaceutical Co., Ltd. (CN) 2014-04-22 — — US disclosed
WO-2014032627-A1 NEW PROCESS ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD (CN) 2014-03-06 — — WO disclosed
US-20120016151-A1 PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID NOVARTIS AG (CH) 2012-01-19 — — US disclosed
EP-2387558-A1 PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID Zhejiang Jiuzhou Pharmaceutical Co., Ltd. (CN) 2011-11-23 — — EP disclosed
US-20110253230-A1 Temperature Sensitive Valve Having Shape Memory Actuator OMNITEK PARTNERS LLC (US) 2011-10-20 — — US disclosed
WO-2010081410-A1 PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) 2010-07-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150210632-A1 NEW PROCESS MME, DNPEP, ACE CXCL8 4877/4885HSP90AA1 3495/4885HSP90AB1 2822/4885
US-20140179947-A1 PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID DNPEP, MME, DPP7 CXCL8 4581/4885HSP90AA1 4094/4885HSP90AB1 4264/4885
US-20120016151-A1 PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID DNPEP, MME, DPP7 CXCL8 4581/4885HSP90AA1 4094/4885HSP90AB1 4264/4885
US-10183909-B2 Process for preparation of N-Boc biphenyl alaninol RABL6, PF4, SPIN4 CXCL8 4103/4885HSP90AA1 4310/4885HSP90AB1 4114/4885
US-20180297941-A1 PROCESS FOR PREPARATION OF N-BOC BIPHENYL ALANINOL RABL6, DBF4, SPIN4 CXCL8 4115/4885HSP90AA1 4323/4885HSP90AB1 4129/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.