SCHEMBL3398110

SCHEMBL3398110

CC(C)COC(=O)N1CCC(=Cc2cccc(-c3cccc(C#N)c3)c2)CC1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 5/20 0.52
CYP1A2 P05177 2/20 0.52
HRH2 P25021 1/20 0.46
HRH1 P35367 1/20 0.46
CYP3A4 P08684 3/20 0.42
MGLL Q99685 2/20 0.42
PDE4D Q08499 1/20 0.41
MCHR1 Q99705 2/20 0.40
CACNA1F O60840 1/20 0.39
CACNA1D Q01668 1/20 0.39
CACNA1S Q13698 1/20 0.39
CACNA1C Q13936 1/20 0.39
KDM1A O60341 1/20 0.37
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
PDCD1 Q15116 1/20 0.37
CD274 Q9NZQ7 1/20 0.37
CHRM3 P20309 1/20 0.37
GPR119 Q8TDV5 1/20 0.37
PRMT5 O14744 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1363015 0.83 GRM5 (0.48) GRM5CYP1A2HRH2HRH1CYP3A4
SCHEMBL8017992 0.82 GRM5 (0.47) GRM5CYP1A2HRH2HRH1CYP3A4
SCHEMBL3400652 0.80 MCL1 (0.41) GRM5CYP1A2HRH1CYP3A4GPR119
SCHEMBL4050891 0.78 HRH2 (0.55) HRH2HRH1MGLLCHRM3
SCHEMBL6393733 0.76 GRM5 (0.51) GRM5CYP1A2CYP3A4MGLLGPR119
SCHEMBL3397620 0.76 GPR119 (0.38) GRM5CYP1A2HRH1CYP3A4GPR119
SCHEMBL6399053 0.74 GRM5 (0.46) GRM5CYP1A2MGLLMAOAMAOB
SCHEMBL3919400 0.71 KDM4E (0.54) GRM5CYP1A2CYP3A4MGLLCACNA1F
SCHEMBL1583452 0.69 GRM5 (0.46) GRM5CYP1A2HRH2HRH1MGLL
SCHEMBL9140000 0.68 LSS (0.49) GRM5CYP1A2CYP3A4MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2259681-A1 DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-12-15 EP disclosed
EP-2249646-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-11-17 EP disclosed
EP-2249647-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-11-17 EP disclosed
EP-2249830-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-11-17 EP disclosed
EP-2247184-A1 DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-11-10 EP disclosed
WO-2009100167-A1 DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed
WO-2009100169-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed
WO-2009100168-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed
WO-2009100170-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed
WO-2009100166-A1 DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed