SCHEMBL3400652

SCHEMBL3400652

CC(C)COC(=O)N1CCC(=Cc2cccc(Br)c2)CC1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
GRM5 P41594 5/20 0.40
CYP3A4 P08684 3/20 0.40
CYP1A2 P05177 3/20 0.40
GPR119 Q8TDV5 1/20 0.40
HRH1 P35367 1/20 0.39
SLC6A15 Q9H2J7 1/20 0.39
HSD11B1 P28845 1/20 0.39
SRD5A1 P18405 1/20 0.39
KIT P10721 1/20 0.39
HTT P42858 1/20 0.37
XDH P47989 1/20 0.37
HDAC2 Q92769 1/20 0.37
ALDH1A1 P00352 1/20 0.37
MAPT P10636 1/20 0.37
HSD17B10 Q99714 1/20 0.37
MAP3K5 Q99683 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23303315 0.82 HDAC2 (0.55) MCL1SMN1; SMN2GRM5CYP3A4CYP1A2
SCHEMBL3397620 0.81 GPR119 (0.38) GRM5CYP3A4CYP1A2GPR119HRH1
SCHEMBL3398110 0.80 GRM5 (0.52) GRM5CYP3A4CYP1A2GPR119HRH1
SCHEMBL1363915 0.80 GRM5 (0.47) GRM5GPR119HSD11B1SRD5A1XDH
SCHEMBL8017704 0.79 HSD11B1 (0.41) SMN1; SMN2GRM5CYP3A4CYP1A2HSD11B1
SCHEMBL5211605 0.78 HSD11B1 (0.49) SMN1; SMN2HSD11B1SRD5A1HTTXDH
SCHEMBL2587701 0.77 GRM5 (0.39) GRM5CYP3A4CYP1A2HRH1SLC6A15
SCHEMBL4054843 0.74 KDM4E (0.56) SMN1; SMN2HTTALDH1A1
SCHEMBL22112364 0.74 ESR2 (0.46) GRM5GPR119HSD11B1XDHMAPT
SCHEMBL3399260 0.73 GPR119 (0.47) SMN1; SMN2GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2259681-A1 DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-12-15 EP disclosed
EP-2249646-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-11-17 EP disclosed
EP-2249830-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-11-17 EP disclosed
EP-2249647-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-11-17 EP disclosed
EP-2247184-A1 DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS Glaxo Group Limited (GB) 2010-11-10 EP disclosed
WO-2009100170-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed
WO-2009100168-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed
WO-2009100169-A1 DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed
WO-2009100167-A1 DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed
WO-2009100166-A1 DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS GLAXO GROUP LIMITED (GB) 2009-08-13 WO disclosed