Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | LPL | P06858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13750914 | 0.87 | SRD5A1 (0.38) | GPR119GRM5CYP3A4CYP1A2SLC6A15 | |
| SCHEMBL3397617 | 0.83 | USP30 (0.42) | GPR119GRM5AAK1 | |
| SCHEMBL3400652 | 0.81 | MCL1 (0.41) | GPR119GRM5CYP3A4CYP1A2HRH1 | |
| SCHEMBL1985044 | 0.80 | ALDH1A1 (0.41) | KIT | |
| SCHEMBL3399223 | 0.77 | PRMT5 (0.42) | LIPGPPARGPPARALPL | |
| SCHEMBL3398110 | 0.76 | GRM5 (0.52) | GPR119GRM5CYP3A4CYP1A2HRH1 | |
| SCHEMBL22866678 | 0.71 | ALDH1A1 (0.43) | LIPGAAK1LPL | |
| SCHEMBL8026194 | 0.71 | GRM5 (0.38) | GPR119GRM5OGA | |
| SCHEMBL2374094 | 0.71 | GPR119 (0.42) | GPR119ROCK1AAK1 | |
| SCHEMBL4012501 | 0.71 | P2RX7 (0.38) | GPR119HRH1SLC6A15KITPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247184-A1 | DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009100167-A1 | DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |