Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405473 | 0.86 | KDM4E (0.47) | KMT2AMEN1KDM4EALDH1A1POLB | |
| SCHEMBL2200588 | 0.85 | KMT2A (0.51) | KMT2AMEN1ALDH1A1POLBNPSR1 | |
| SCHEMBL2200244 | 0.83 | KMT2A (0.55) | KMT2AMEN1POLBMAPTRAB9A | |
| SCHEMBL3403915 | 0.82 | KMT2A (0.48) | KMT2AMEN1KDM4EALDH1A1POLB | |
| SCHEMBL2200597 | 0.81 | KMT2A (0.46) | KMT2AMEN1KDM4EALDH1A1POLB | |
| SCHEMBL2200600 | 0.81 | KMT2A (0.46) | KMT2AMEN1KDM4EALDH1A1POLB | |
| SCHEMBL3402331 | 0.80 | KMT2A (0.64) | KMT2AMEN1ALDH1A1POLBMAPT | |
| SCHEMBL3400876 | 0.79 | LMNA (0.48) | KMT2AMEN1KDM4EALDH1A1RAB9A | |
| SCHEMBL2202742 | 0.79 | KMT2A (0.50) | KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL13973728 | 0.78 | ALDH1A1 (0.39) | KMT2AMEN1KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |