Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401265 | 0.94 | KCNMA1 (0.44) | MTORKCNMA1KDM4EALDH1A1POLB | |
| SCHEMBL3397799 | 0.90 | GSK3B (0.44) | MTORGSK3B | |
| SCHEMBL2066032 | 0.90 | F10 (0.45) | F10KCNMA1TP53GSK3BFLT1 | |
| SCHEMBL927355 | 0.90 | GSK3B (0.39) | MTORF10GSK3B | |
| SCHEMBL2065921 | 0.88 | F10 (0.45) | F10KCNMA1ALDH1A1TP53 | |
| SCHEMBL3663404 | 0.85 | GSK3B (0.41) | F10KCNMA1TP53GSK3B | |
| SCHEMBL3402354 | 0.85 | RAB9A (0.36) | MTORALDH1A1GSK3BPOLBSMN1; SMN2 | |
| SCHEMBL3425658 | 0.83 | KCNMA1 (0.40) | MTORKCNMA1KDM4EALDH1A1GSK3B | |
| SCHEMBL3663467 | 0.82 | F10 (0.39) | F10LMNA | |
| SCHEMBL2066338 | 0.81 | KCNMA1 (0.46) | KCNMA1KDM4EALDH1A1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247599-A1 | SUBSTITUTED ARYLAMIDE OXAZEPINOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009095788-A1 | SUBSTITUTED ARYLAMIDE OXAZEPINOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2009-08-06 | — | — | WO | disclosed |