Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 12/20 | 0.61 |
| ▸ | PPARD | Q03181 | 5/20 | 0.61 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405464 | 0.99 | PPARA (0.60) | PPARAPPARDPPARGCHRM4SCN9A | |
| SCHEMBL3403571 | 0.94 | PPARA (0.58) | PPARAPPARDPPARGCHRM4NPC1 | |
| SCHEMBL3398904 | 0.89 | POLB (0.60) | PPARAPPARDCHRM4SCN9ANPC1 | |
| SCHEMBL3398475 | 0.89 | PPARA (0.49) | PPARAPPARDPPARGCHRM4SCN9A | |
| SCHEMBL3399733 | 0.88 | GLS (0.48) | PPARAPPARDCHRM4SCN9ANPC1 | |
| SCHEMBL3403462 | 0.87 | CHRM4 (0.65) | PPARAPPARDPPARGCHRM4NPC1 | |
| SCHEMBL3398969 | 0.86 | HPGD (0.55) | PPARAPPARDCHRM4SCN9ANPC1 | |
| SCHEMBL3405206 | 0.86 | GLA (0.60) | PPARACHRM4SCN9ANPC1ALDH1A1 | |
| SCHEMBL3398806 | 0.85 | CHRM4 (0.54) | PPARAPPARDCHRM4SCN9ANPC1 | |
| SCHEMBL3399982 | 0.85 | PPARA (0.57) | PPARAPPARDPPARGCHRM4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |