Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 4/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3670674 | 0.92 | DRD3 (0.41) | HTR6DRD2DRD3SMN1; SMN2 | |
| SCHEMBL677032 | 0.85 | HTR6 (0.42) | HTR6KDRMAPT | |
| SCHEMBL3398885 | 0.84 | LSS (0.45) | LSSHTR6FGFR1SRCSLC2A1 | |
| SCHEMBL3662668 | 0.84 | HTR6 (0.42) | HTR6SRCHTR1ADRD2HTR7 | |
| SCHEMBL3664144 | 0.84 | NPC1 (0.43) | HTR6KDRCXCR1HTR1AHTR7 | |
| SCHEMBL675896 | 0.80 | SRC (0.40) | HTR6SRCMAPTSMN1; SMN2 | |
| SCHEMBL3424943 | 0.78 | NPC1 (0.38) | HTR6SRCKDRCXCR1HTR1A | |
| SCHEMBL23862909 | 0.78 | METAP2 (0.38) | HTR6DRD2HTR7 | |
| SCHEMBL3670473 | 0.77 | PTGDR2 (0.42) | HTR6SRCSMN1; SMN2 | |
| SCHEMBL675362 | 0.77 | DRD3 (0.41) | HTR6DRD2DRD3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| WO-2010025872-A2 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2010-03-11 | — | — | WO | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |