Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402710 | 0.81 | EDNRB (0.50) | TOP2AKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL3398684 | 0.78 | KDM4E (0.46) | KDM4ECXCR3MEN1KMT2ARAB9A | |
| SCHEMBL1060629 | 0.74 | L3MBTL1 (0.67) | KDM4EMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL1061190 | 0.73 | KDM4E (0.53) | KDM4EMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL13708877 | 0.72 | KDM4E (0.51) | KDM4EMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL27854511 | 0.71 | MAPK1 (0.46) | KDM4EMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL1062395 | 0.66 | KDM4E (0.51) | KDM4EMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL1128275 | 0.65 | FNTA (0.68) | KDM4ECXCR3RAB9ATNFALDH1A1 | |
| SCHEMBL11138734 | 0.65 | TOP2A (0.59) | TOP2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1056833 | 0.65 | KDM4E (0.50) | KDM4EMEN1KMT2AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247588-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009107850-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-03 | — | — | WO | disclosed |