Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398679 | 0.81 | TOP2A (0.50) | KDM4EMAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3402714 | 0.80 | EDNRB (0.51) | EDNRBKDM4EMAPK1HTTSMN1; SMN2 | |
| SCHEMBL27836563 | 0.77 | P2RX4 (0.61) | EDNRBKDM4EMAPK1HTTSMN1; SMN2 | |
| SCHEMBL27806349 | 0.76 | KDM4E (0.54) | EDNRBKDM4EMAPK1HTTSMN1; SMN2 | |
| SCHEMBL1061448 | 0.76 | L3MBTL1 (0.65) | EDNRBKDM4EMAPK1HTTSMN1; SMN2 | |
| SCHEMBL1063193 | 0.74 | FEN1 (0.51) | EDNRBKDM4EMAPK1HTTSMN1; SMN2 | |
| SCHEMBL10487954 | 0.74 | MEN1 (0.60) | KDM4ESMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL14780906 | 0.73 | FEN1 (0.54) | EDNRBKDM4EMAPK1HTTSMN1; SMN2 | |
| SCHEMBL25312176 | 0.70 | ALDH1A1 (0.62) | HTTSMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL11263773 | 0.69 | MEN1 (0.72) | KDM4EMAPK1HTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247588-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009107850-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-03 | — | — | WO | disclosed |