Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1061190 | 0.93 | KDM4E (0.53) | KDM4EMEN1KMT2ARAB9ATDP1 | |
| SCHEMBL13708877 | 0.83 | KDM4E (0.51) | KDM4EMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL3402714 | 0.81 | EDNRB (0.51) | KDM4EMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL3398679 | 0.78 | TOP2A (0.50) | KDM4EMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL1060629 | 0.75 | L3MBTL1 (0.67) | KDM4EMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL27854511 | 0.73 | MAPK1 (0.46) | KDM4EMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL1063193 | 0.73 | FEN1 (0.51) | KDM4EMEN1KMT2AL3MBTL1POLB | |
| SCHEMBL1062407 | 0.72 | SMN1; SMN2 (0.43) | KDM4EMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL13838704 | 0.68 | ALDH1A1 (0.62) | KDM4EMEN1KMT2AL3MBTL1POLB | |
| SCHEMBL557889 | 0.68 | SMN1; SMN2 (0.55) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247588-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009107850-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-03 | — | — | WO | disclosed |