Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30462500 | 0.84 | FABP4 (0.52) | CXCR5ALDH1A1KDM4CKDM5AKDM4E | |
| SCHEMBL28549841 | 0.84 | FABP4 (0.52) | CXCR5ALDH1A1KDM4CKDM5AKDM4E | |
| SCHEMBL27248573 | 0.82 | CXCR5 (0.60) | CXCR5ALDH1A1KDM4CKDM5ANR1H4 | |
| SCHEMBL3397688 | 0.80 | CXCR5 (0.38) | THRATHRBCXCR5HPGDPARP15 | |
| SCHEMBL21828877 | 0.78 | HSD17B10 (0.51) | THRBALDH1A1MAPK1KDM4EHPGD | |
| SCHEMBL6058165 | 0.77 | THRA (0.49) | THRATHRBPARP15PARP10PARP2 | |
| SCHEMBL6771711 | 0.75 | KDM4E (0.54) | THRATHRBCXCR5ALDH1A1KDM4E | |
| SCHEMBL6770208 | 0.75 | FABP4 (0.53) | THRATHRBALDH1A1PARP15PARP10 | |
| SCHEMBL6770847 | 0.74 | PARP15 (0.49) | MAPK1HPGDPARP15PARP10MAPK8 | |
| SCHEMBL6766362 | 0.74 | PARP15 (0.46) | MAPK1HPGDPARP15PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103626-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |