Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836629 | 0.86 | KDR (0.60) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3395422 | 0.81 | NPC1 (0.61) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL27617535 | 0.80 | KDR (0.68) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL27679373 | 0.78 | HDAC6 (0.58) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2641717 | 0.77 | HDAC1 (0.81) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL14461305 | 0.76 | HDAC1 (0.72) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL27599000 | 0.76 | HDAC1 (0.67) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL12895711 | 0.76 | RAB9A (0.59) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL27866684 | 0.76 | NPC1 (0.80) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL14075128 | 0.75 | RAB9A (0.55) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015703-A2 | NOVEL 6-O-SUBSTITUTED 15-MEMBERED 8A- AND 9A-LACTAMS | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2010-02-11 | — | — | WO | disclosed |