Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.56 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1193017 | 0.87 | NPC1 (0.63) | NPC1POLBMAPTMEN1KMT2A | |
| SCHEMBL1193628 | 0.83 | ALDH1A1 (0.60) | NPC1POLBMAPTMEN1KMT2A | |
| SCHEMBL3398749 | 0.81 | RAB9A (0.56) | NPC1POLBMAPTMEN1KMT2A | |
| SCHEMBL27599138 | 0.80 | NPC1 (0.77) | NPC1POLBMAPTMEN1KMT2A | |
| SCHEMBL1193623 | 0.80 | ALOX5 (0.56) | NPC1POLBMAPTMEN1KMT2A | |
| SCHEMBL2639005 | 0.77 | HDAC6 (0.69) | NPC1POLBMAPTMEN1KMT2A | |
| SCHEMBL29944526 | 0.77 | NPC1 (0.77) | NPC1POLBMAPTMEN1KMT2A | |
| SCHEMBL5142389 | 0.77 | NPC1 (0.77) | NPC1POLBMAPTMEN1KMT2A | |
| SCHEMBL8209526 | 0.77 | NPC1 (0.48) | NPC1POLBMAPTMEN1KMT2A | |
| SCHEMBL27599014 | 0.77 | NPC1 (0.70) | NPC1POLBMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015703-A2 | NOVEL 6-O-SUBSTITUTED 15-MEMBERED 8A- AND 9A-LACTAMS | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2010-02-11 | — | — | WO | disclosed |