Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405267 | 0.90 | ALDH1A1 (0.63) | PPARAALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL3399563 | 0.85 | HTR2C (0.43) | PPARAALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL3405714 | 0.85 | HTR2C (0.45) | PPARAALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL3404493 | 0.83 | KMT2A (0.44) | PPARAALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL13309741 | 0.83 | RAB9A (0.56) | PPARAALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL3403383 | 0.82 | PPARA (0.44) | PPARAALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL3405487 | 0.82 | HTR2C (0.44) | PPARAALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL3404554 | 0.81 | HTR2C (0.44) | PPARAALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL3400845 | 0.81 | PPARA (0.51) | PPARAALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL3404118 | 0.80 | PPARA (0.57) | PPARAALDH1A1NPC1GAAHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |