Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AGPAT2 | O15120 | 3/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405318 | 0.87 | HTR2C (0.47) | HTR2CALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL3403383 | 0.83 | PPARA (0.44) | HTR2CPPARAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3401263 | 0.83 | HTR2C (0.57) | HTR2CALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL3405267 | 0.82 | ALDH1A1 (0.63) | HTR2CPPARAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3398779 | 0.82 | PPARA (0.48) | HTR2CPPARAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL13071981 | 0.81 | MAPT (0.52) | HTR2CALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL3401487 | 0.81 | HTR2C (0.55) | HTR2CPPARAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3403876 | 0.80 | KMT2A (0.45) | HTR2CPPARAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3399781 | 0.79 | HTR2C (0.46) | HTR2CALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL5048868 | 0.79 | SMN1; SMN2 (0.62) | ALDH1A1SMN1; SMN2NPC1GAAAGPAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |