Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405005 | 0.91 | THRA (0.46) | ALDH1A1SMN1; SMN2CNR1THRATHRB | |
| SCHEMBL3404767 | 0.91 | THRA (0.46) | ALDH1A1SMN1; SMN2CNR1THRATHRB | |
| SCHEMBL3404145 | 0.90 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CNR1HPGDTHRA | |
| SCHEMBL3405561 | 0.90 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2CNR1HPGDTHRA | |
| SCHEMBL3402530 | 0.86 | CNR1 (0.47) | ALDH1A1SMN1; SMN2CNR1HPGDTHRA | |
| SCHEMBL3405619 | 0.86 | CNR1 (0.48) | ALDH1A1SMN1; SMN2CNR1HPGDTHRA | |
| SCHEMBL3398941 | 0.84 | CNR1 (0.47) | ALDH1A1SMN1; SMN2CNR1HPGDTHRA | |
| SCHEMBL3403718 | 0.84 | CNR1 (0.54) | ALDH1A1SMN1; SMN2CNR1HPGDTHRA | |
| SCHEMBL3402380 | 0.83 | THRA (0.45) | ALDH1A1SMN1; SMN2CNR1HPGDTHRA | |
| SCHEMBL3399714 | 0.83 | HTR2C (0.43) | ALDH1A1SMN1; SMN2HPGDLMNASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |