Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.38 |
| ▸ | PPARA | Q07869 | 4/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5184347 | 0.86 | PDE4A (0.43) | PPARGPPARAPDE4APDE4BPDE4C | |
| SCHEMBL1567905 | 0.85 | PPARG (0.36) | PPARGPPARACACNA1HPDE4APDE4B | |
| SCHEMBL12474333 | 0.85 | CACNA1H (0.37) | PPARGPPARACACNA1HPDE4APDE4B | |
| SCHEMBL17423572 | 0.85 | CSNK2A1 (0.41) | PPARGPPARA | |
| SCHEMBL5184176 | 0.81 | ALOX15 (0.39) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL3397681 | 0.81 | ALDH1A1 (0.42) | PPARGPPARAPDE4APDE4BPDE4C | |
| SCHEMBL24852156 | 0.79 | PPARG (0.40) | PPARGPPARACACNA1HPDE4APDE4B | |
| SCHEMBL2440368 | 0.79 | CSNK2A1 (0.45) | PPARGPPARACACNA1HPDE4APDE4B | |
| SCHEMBL12967349 | 0.79 | CACNA1H (0.39) | PPARGPPARACACNA1H | |
| SCHEMBL16953563 | 0.79 | PDE4A (0.44) | PPARGPPARACACNA1HPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103626-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |