Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.32 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL3399221 | 1.00 | TSHR (0.43) | TSHRTP53EGLN1EGLN3TDP1 | |
| SCHEMBL7814132 | 0.87 | — | — | |
| SCHEMBL640316 | 0.87 | — | — | |
| SCHEMBL2782669 | 0.87 | — | — | |
| SCHEMBL7934102 | 0.85 | TDP1 (0.48) | TSHRTDP1SMN1; SMN2SLC22A6LMNA | |
| Ammonia Solution, Strong SCHEMBL11366639 | 0.85 | TDP1 (0.55) | TSHRTDP1SMN1; SMN2SLC22A6LMNA | |
| Ammonia Solution, Strong SCHEMBL8428638 | 0.85 | TDP1 (0.55) | TSHRTDP1SMN1; SMN2SLC22A6LMNA | |
| Hydrochloric Acid SCHEMBL9622278 | 0.85 | TDP1 (0.48) | TSHRTDP1SMN1; SMN2SLC22A6LMNA | |
| Malic Acid SCHEMBL9719878 | 0.73 | SMN1; SMN2 (0.75) | TSHRTP53EGLN1EGLN3TDP1 | |
| Malic Acid SCHEMBL3061502 | 0.73 | SMN1; SMN2 (0.75) | TSHRTP53EGLN1EGLN3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2174909-A1 | Composition comprising a layered double hydroxide | Akzo Nobel N.V. (NL) | 2010-04-14 | — | — | EP | disclosed |