Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.47 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3914633 | 0.86 | MLNR (0.49) | GPR119LNPEPHRH3MEN1KMT2A | |
| SCHEMBL4620879 | 0.86 | GPR119 (0.47) | GPR119HRH3MEN1KMT2A | |
| SCHEMBL23301488 | 0.82 | SMN1; SMN2 (0.57) | GPR119LNPEPMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29942602 | 0.82 | SMN1; SMN2 (0.57) | GPR119LNPEPMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3618820 | 0.80 | LNPEP (0.48) | GPR119LNPEPMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL30740748 | 0.80 | GPR119 (0.55) | GPR119HRH3MEN1KMT2A | |
| SCHEMBL1364255 | 0.80 | GPR119 (0.55) | GPR119HRH3MEN1KMT2A | |
| SCHEMBL3396290 | 0.80 | PRMT5 (0.47) | HRH3MEN1KMT2A | |
| SCHEMBL14746764 | 0.79 | SCD (0.48) | GPR119EPHX2SMN1; SMN2 | |
| SCHEMBL15637209 | 0.79 | SLC6A2 (0.50) | EPHX2SLC6A2SLC6A4SLC6A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249647-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009100168-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |