SCHEMBL3399496

SCHEMBL3399496

CC(C)Oc1ccccc1-c1cnnc(N)n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 1/20 0.47
ALOX5AP P20292 1/20 0.43
FEN1 P39748 1/20 0.43
HSP90AA1 P07900 2/20 0.41
HSP90AB1 P08238 1/20 0.40
MCHR1 Q99705 2/20 0.40
TLR8 Q9NR97 1/20 0.40
ADORA2A P29274 1/20 0.40
ADORA1 P30542 1/20 0.40
MAOB P27338 1/20 0.38
CCNT1 O60563 1/20 0.37
CCNA2 P20248 1/20 0.37
CDK2 P24941 1/20 0.37
CDK9 P50750 1/20 0.37
CCNA1 P78396 1/20 0.37
CDK5 Q00535 1/20 0.37
CDK5R1 Q15078 1/20 0.37
IRAK4 Q9NWZ3 1/20 0.36
KCNN4 O15554 1/20 0.36
PDE5A O76074 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3393510 0.85 ADORA2A (0.40) CHRNA7ALOX5APFEN1HSP90AA1HSP90AB1
SCHEMBL3393346 0.83 HSP90AA1 (0.59) CHRNA7HSP90AA1HSP90AB1ADORA2AADORA1
SCHEMBL3397291 0.79 MAOB (0.47) HSP90AA1HSP90AB1TLR8ADORA2AADORA1
SCHEMBL28501601 0.78 CDK5 (0.59) CHRNA7ALOX5APFEN1HSP90AA1HSP90AB1
SCHEMBL30507533 0.78 CDK5 (0.59) CHRNA7ALOX5APFEN1HSP90AA1HSP90AB1
SCHEMBL3394031 0.78 NCOA1 (0.44) FEN1HSP90AA1HSP90AB1ADORA2AADORA1
SCHEMBL3392494 0.77 ATR (0.48) ALOX5APFEN1HSP90AA1HSP90AB1ADORA2A
SCHEMBL3398117 0.77 MPL (0.44) ALOX5APFEN1HSP90AA1ADORA2AADORA1
SCHEMBL13425651 0.76 CYP1A2 (0.49) MCHR1TLR8MAOBPDE5A
SCHEMBL13425393 0.74 CYP11B2 (0.47) HSP90AA1TLR8ADORA2AADORA1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed