SCHEMBL3400124

SCHEMBL3400124

N=C(NS)N(c1ccccc1)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.44
ALDH1A1 P00352 3/20 0.41
L3MBTL1 Q9Y468 4/20 0.40
KMT2A Q03164 3/20 0.40
MEN1 O00255 2/20 0.40
HPGD P15428 2/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
NPC1 O15118 1/20 0.38
POLB P06746 1/20 0.38
HTT P42858 1/20 0.38
RAB9A P51151 1/20 0.38
ATM Q13315 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
TRPM8 Q7Z2W7 1/20 0.34
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2481899 0.79 NPSR1 (0.46) NPSR1ALDH1A1L3MBTL1KMT2AMEN1
SCHEMBL5961422 0.77 ALDH1A1 (0.46) NPSR1ALDH1A1L3MBTL1KMT2AMEN1
SCHEMBL4099517 0.77 L3MBTL1 (0.45) NPSR1ALDH1A1L3MBTL1KMT2AMEN1
SCHEMBL1792956 0.76 ALDH1A1 (0.43) NPSR1ALDH1A1L3MBTL1KMT2AMEN1
SCHEMBL109209 0.76 ALDH1A1 (0.43) NPSR1ALDH1A1L3MBTL1KMT2AMEN1
SCHEMBL7078589 0.75 ALDH1A1 (0.45) NPSR1ALDH1A1L3MBTL1KMT2AMEN1
SCHEMBL3058170 0.74 ALDH1A1 (0.48) NPSR1ALDH1A1L3MBTL1KMT2AMEN1
Hydrochloric Acid SCHEMBL3143822 0.74 ALDH1A1 (0.41) NPSR1ALDH1A1L3MBTL1KMT2AMEN1
SCHEMBL36862 0.73 ALDH1A1 (0.58) NPSR1ALDH1A1L3MBTL1KMT2AMEN1
SCHEMBL1797820 0.73 ALDH1A1 (0.58) NPSR1ALDH1A1L3MBTL1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105367851-B The rubber prepared using pretreated precipitated silica and the tire with component 固特异轮胎和橡胶公司 2018-01-16 CN claimed
EP-3296354-B1 RUBBER COMPOSITION AND TIRE WITH TREAD INTENDED FOR OFF-THE-ROAD SERVICE GOODYEAR TIRE & RUBBER (US) 2021-06-30 EP disclosed
CN-107840998-B Tire with tread intended for off-road use 固特异轮胎和橡胶公司 2020-10-30 CN disclosed
CN-111171401-A Footwear and rubber sole comprising dual silica portions 固特异轮胎和橡胶公司 2020-05-19 CN disclosed
EP-3326837-B1 RUBBER COMPOSITION CONTAINING SOYBEAN OIL AND TIRE WITH COMPONENT GOODYEAR TIRE & RUBBER (US) 2019-07-24 EP disclosed
EP-3181624-B1 RUBBER COMPOSITION CONTAINING ALGAE OIL AND TIRE WITH COMPONENT GOODYEAR TIRE & RUBBER (US) 2018-10-24 EP disclosed
US-20180148566-A1 RUBBER COMPOSITION CONTAINING SPECIALIZED SOYBEAN OIL AND TIRE WITH COMPONENT GOODYEAR TIRE & RUBBER COMPANY, THE 2018-05-31 US disclosed
EP-3326837-A1 RUBBER COMPOSITION CONTAINING SOYBEAN OIL AND TIRE WITH COMPONENT The Goodyear Tire & Rubber Company (US) 2018-05-30 EP disclosed
CN-107840998-A Tire with the tyre surface for being intended for cross-country purposes 固特异轮胎和橡胶公司 2018-03-27 CN disclosed
US-20180079892-A1 TIRE WITH TREAD INTENDED FOR OFF-THE-ROAD SERVICE GOODYEAR TIRE & RUBBER COMPANY, THE 2018-03-22 US disclosed
US-9574066-B1 Rubber composition containing algae oil and tire with component THE GOODYEAR TIRE & RUBBER COMPANY (US) 2017-02-21 US disclosed
EP-2090615-B1 Rubber with combination of silica and partially decarboxylated rosin acid and tire with component thereof GOODYEAR TIRE & RUBBER (US) 2016-07-20 EP disclosed
US-20130340909-A1 TIRE WITH COMPOSITE OF CHAFER AND OUTER SIDEWALL RUBBER LAYER COMPONENTS GOODYEAR TIRE & RUBBER COMPANY, THE 2013-12-26 US disclosed
CN-101831092-B Tire with a tread of polybutadiene rubber GOODYEAR TIRE & RUBBER 2012-05-09 CN disclosed
CN-101831092-A Tire with tread of polybutadiene rubber GOODYEAR TIRE & RUBBER 2010-09-15 CN disclosed
US-7737204-B2 Tire made of a conjugated diene-based elastomer; carbon black/participated silica filler; coupler; rubber processing oil mixture of partially decarboxylated non-petroleum, plant-derived rosin oil and petroleum based processing oil; improved tear resistance and wear resistance THE GOODYEAR TIRE & RUBBER COMPANY (US) 2010-06-15 US disclosed
US-20090209690-A1 Tire made of a conjugated diene-based elastomer; carbon black/participated silica filler; coupler; rubber processing oil mixture of partially decarboxylated non-petroleum, plant-derived rosin oil and petroleum based processing oil; improved tear resistance and wear resistance GOODYEAR TIRE & RUBBER COMPANY, THE 2009-08-20 US disclosed
EP-2090615-A1 Rubber with combination of silica and partially decarboxylated rosin acid and tire with component thereof THE GOODYEAR TIRE & RUBBER COMPANY (US) 2009-08-19 EP disclosed
WO-2001021688-A1 FASTER CURING RUBBER ARTICLES THE GOODYEAR TIRE & RUBBER COMPANY (US) 2001-03-29 WO disclosed
US-5677354-A SUBJECTING TO SOLVENT TO SWELL RUBBER, FORCING THROUGH RESTRICTION MEANS HAVING OPENINGS, ADDING DEVULCANIZING AGENTS TO SWOLLEN RUBBER OLIVEIRA DA CUNHA LIMA LUIZ CA (BR) 1997-10-14 US disclosed