Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
| ▸ | L3MBTL3 | Q96JM7 | 7/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ARG1 | P05089 | 1/20 | 0.36 |
| ▸ | ARG2 | P78540 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.34 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.34 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402669 | 1.00 | HTR6 (0.56) | HTR6L3MBTL3L3MBTL1KDM4EMAPT | |
| SCHEMBL3430556 | 0.89 | L3MBTL3 (0.49) | HTR6L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| [1,4']Bipiperidinyl SCHEMBL4727341 | 0.87 | L3MBTL3 (0.48) | HTR6L3MBTL3L3MBTL1KDM4EKMT2A | |
| SCHEMBL238942 | 0.84 | HTR6 (0.75) | HTR6L3MBTL3L3MBTL1ARG1ARG2 | |
| SCHEMBL223255 | 0.84 | HTR6 (0.75) | HTR6L3MBTL3L3MBTL1ARG1ARG2 | |
| SCHEMBL1447785 | 0.84 | HTR6 (0.75) | HTR6L3MBTL3L3MBTL1ARG1ARG2 | |
| Hydrochloric Acid SCHEMBL1814485 | 0.82 | HTR6 (0.72) | HTR6L3MBTL3L3MBTL1KMT2AMBTD1 | |
| Hydrochloric Acid SCHEMBL3335525 | 0.82 | HTR6 (0.72) | HTR6L3MBTL3L3MBTL1KMT2AMBTD1 | |
| Hydrochloric Acid SCHEMBL1809050 | 0.82 | HTR6 (0.72) | HTR6L3MBTL3L3MBTL1KMT2AMBTD1 | |
| SCHEMBL10265670 | 0.82 | HTR6 (0.72) | HTR6L3MBTL3L3MBTL1CYP2D6MBTD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250167-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | Chlorion Pharma, Inc. (CA) | 2010-11-17 | — | — | EP | disclosed |
| US-20090275538-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | UNIVERSITE LAVAL (CA) | 2009-11-05 | — | — | US | disclosed |
| WO-2009097695-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | CHLORION PHARMA, INC. (CA) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275538-A1 | ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS | OPRL1, OPRK1, AHR | HTR6 246/4885L3MBTL3 2314/4885L3MBTL1 3557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.