Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.49 |
| ▸ | VEGFA | P15692 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4296908 | 0.95 | NR1H2 (0.50) | NR1H2VEGFAEGLN1CA12CA1 | |
| SCHEMBL4291723 | 0.86 | NR1H2 (0.50) | NR1H2VEGFAEGLN1CA12CA1 | |
| SCHEMBL4502120 | 0.83 | VEGFA (0.49) | VEGFAEGLN1KMT2AMEN1CHRM2 | |
| SCHEMBL4298566 | 0.83 | VEGFA (0.52) | NR1H2VEGFAEGLN1CA12CA1 | |
| SCHEMBL13333662 | 0.82 | VEGFA (0.48) | NR1H2VEGFAEGLN1CA12CA1 | |
| SCHEMBL3396724 | 0.82 | NR1H2 (0.60) | NR1H2KMT2AMAPK1LMNAALDH1A1 | |
| SCHEMBL22172319 | 0.81 | ALDH1A1 (0.54) | NR1H2VEGFAEGLN1CA12CA1 | |
| SCHEMBL3401719 | 0.80 | IRAK4 (0.39) | NR1H2VEGFAEGLN1MAPK1ALDH1A1 | |
| SCHEMBL3400888 | 0.79 | KMT2A (0.54) | NR1H2VEGFAEGLN1KMT2AMEN1 | |
| SCHEMBL11889589 | 0.79 | NR1H2 (0.46) | NR1H2VEGFAEGLN1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247591-A1 | PYRROLO [2, 3-D]PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009098236-A1 | PYRROLO [2, 3-D] PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-08-13 | — | — | WO | disclosed |