Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.50 |
| ▸ | VEGFA | P15692 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4296908 | 0.90 | NR1H2 (0.50) | NR1H2VEGFAEGLN1CHRM2CHRM4 | |
| SCHEMBL22172319 | 0.87 | ALDH1A1 (0.54) | NR1H2VEGFAEGLN1CHRM2CHRM4 | |
| SCHEMBL3400449 | 0.86 | NR1H2 (0.49) | NR1H2VEGFAEGLN1CHRM2CHRM4 | |
| SCHEMBL30476377 | 0.85 | ALDH1A1 (0.58) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL20818719 | 0.85 | ALDH1A1 (0.58) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL15093922 | 0.85 | MGLL (0.51) | VEGFAEGLN1CHRM2CHRM4CHRM1 | |
| SCHEMBL545916 | 0.85 | NR1H2 (0.62) | NR1H2VEGFAEGLN1CHRM2CHRM4 | |
| SCHEMBL4298566 | 0.84 | VEGFA (0.52) | NR1H2VEGFAEGLN1CHRM2CHRM4 | |
| SCHEMBL13333662 | 0.83 | VEGFA (0.48) | NR1H2VEGFAEGLN1CHRM2CHRM4 | |
| SCHEMBL20150071 | 0.83 | MGLL (0.48) | VEGFAEGLN1CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051255-B2 | Piperazinyl cyclohexane compounds as GPR38 agonists | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-06-09 | — | — | US | disclosed |
| US-20140221392-A1 | CYCLOHEXANE DERIVATIVE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-08-07 | — | — | US | disclosed |
| US-20140221391-A1 | CYCLOHEXANE DERIVATIVE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-08-07 | — | — | US | disclosed |
| EP-2623492-B1 | CYCLOHEXANE DERIVATIVE COMPOUND | DAIICHI SANKYO CO LTD (JP) | 2014-05-14 | — | — | EP | disclosed |
| US-8710060-B2 | Piperazinyl methyl phenyl cyclohexane compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-04-29 | — | — | US | disclosed |
| US-20130289048-A1 | CYCLOHEXANE DERIVATIVE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-10-31 | — | — | US | disclosed |
| EP-2623492-A1 | CYCLOHEXANE DERIVATIVE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-08-07 | — | — | EP | disclosed |
| US-8420657-B2 | Pyrrolo[2,3-D]pyrimidines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2013-04-16 | — | — | US | disclosed |
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | NOVARTIS AG | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221392-A1 | CYCLOHEXANE DERIVATIVE COMPOUND | HRH2, CBR1, HRH4 | NR1H2 63/4885VEGFA 4294/4885EGLN1 502/4885 |
| US-20140221391-A1 | CYCLOHEXANE DERIVATIVE COMPOUND | HRH2, CBR1, HRH4 | NR1H2 63/4885VEGFA 4294/4885EGLN1 502/4885 |
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | ABL1, JAK2, JAK1 | NR1H2 3187/4885VEGFA 3554/4885EGLN1 1935/4885 |
| US-20130289048-A1 | CYCLOHEXANE DERIVATIVE COMPOUND | HRH2, CBR1, HRH4 | NR1H2 63/4885VEGFA 4294/4885EGLN1 502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.