Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285303 | 0.84 | TBK1 (0.47) | ALDH1A1TBK1KDM4EGPR119NR1H2 | |
| SCHEMBL4296908 | 0.83 | NR1H2 (0.50) | ALDH1A1KDM4ENPC1MAPTMAPK1 | |
| SCHEMBL3400449 | 0.80 | NR1H2 (0.49) | ALDH1A1KDM4EMAPK1NR1H2VEGFA | |
| SCHEMBL4290751 | 0.76 | KMT2A (0.48) | GAASMN1; SMN2ALDH1A1TP53MAPT | |
| SCHEMBL3402144 | 0.76 | TRPV6 (0.53) | ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL4291723 | 0.75 | NR1H2 (0.50) | ALDH1A1KDM4ENPC1MAPTMAPK1 | |
| SCHEMBL4502120 | 0.73 | VEGFA (0.49) | ALDH1A1TP53KDM4EGPR119VEGFA | |
| SCHEMBL3709485 | 0.73 | FAAH (0.50) | IRAK4SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL17155190 | 0.72 | KDM5C (0.40) | ALDH1A1TBK1KDM4ENR1H2CCNK | |
| SCHEMBL4298566 | 0.72 | VEGFA (0.52) | SMN1; SMN2ALDH1A1NPC1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247591-A1 | PYRROLO [2, 3-D]PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009098236-A1 | PYRROLO [2, 3-D] PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-08-13 | — | — | WO | disclosed |