Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14949553 | 0.90 | GAA (0.50) | GAAPKMSMN1; SMN2KDM4EMAPT | |
| SCHEMBL2607037 | 0.84 | POLB (0.54) | GAASMN1; SMN2KMT2APOLB | |
| SCHEMBL12436958 | 0.84 | POLB (0.44) | SMN1; SMN2MAPTKMT2APOLB | |
| SCHEMBL3861156 | 0.83 | GAA (0.54) | GAAPKMSMN1; SMN2CHRM1TDP1 | |
| SCHEMBL584259 | 0.81 | GNAI3 (0.51) | PKMMAPTKMT2APOLBTSHR | |
| SCHEMBL3401952 | 0.81 | GAA (0.55) | GAAPKMSMN1; SMN2KDM4EMAPT | |
| SCHEMBL14949558 | 0.80 | ALDH1A1 (0.55) | KDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27080580 | 0.80 | GNAI3 (0.54) | PKMMAPTKMT2APOLBTSHR | |
| SCHEMBL12396072 | 0.79 | GAA (0.62) | GAAPKMSMN1; SMN2CHRM1TDP1 | |
| SCHEMBL7706487 | 0.79 | ALDH1A1 (0.60) | GAAKDM4EMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| WO-2013155223-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-10-17 | — | — | WO | disclosed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |