Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404829 | 0.84 | KMT2A (0.55) | CHRNA7KMT2AHRH3MAPTNPSR1 | |
| SCHEMBL3400876 | 0.82 | LMNA (0.48) | LMNAKMT2AHRH3OPRM1PDE4B | |
| SCHEMBL3401127 | 0.81 | LMNA (0.50) | LMNAKMT2AMAPTNPSR1MEN1 | |
| SCHEMBL3400065 | 0.79 | L3MBTL3 (0.48) | LMNAKMT2AHRH3MEN1ALDH1A1 | |
| SCHEMBL3404126 | 0.79 | L3MBTL3 (0.48) | LMNAKMT2AHRH3MEN1ALDH1A1 | |
| SCHEMBL3402331 | 0.78 | KMT2A (0.64) | LMNAKMT2APDE4DMAPTNPSR1 | |
| SCHEMBL2199807 | 0.77 | KMT2A (0.48) | LMNACHRNA7KMT2AHRH3MAPT | |
| SCHEMBL2199814 | 0.77 | KMT2A (0.48) | LMNACHRNA7KMT2AHRH3MAPT | |
| SCHEMBL13973727 | 0.76 | KMT2A (0.55) | LMNAKMT2APDE4BPDE4DMAPT | |
| SCHEMBL3399691 | 0.74 | KMT2A (0.62) | LMNAKMT2AHRH3PDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |