Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27976218 | 0.82 | CYP2C19 (0.44) | LMNAALDH1A1CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL12238644 | 0.82 | CYP2C19 (0.44) | ALDH1A1CYP2D6CYP2C19HSD17B10MEN1 | |
| SCHEMBL8609442 | 0.81 | LMNA (0.45) | LMNAALDH1A1CYP2D6MEN1KMT2A | |
| SCHEMBL16685441 | 0.79 | MEN1 (0.48) | LMNAMEN1KMT2ANPC1 | |
| SCHEMBL7914381 | 0.78 | CYP2C19 (0.46) | LMNAALDH1A1CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL8235740 | 0.78 | LMNA (0.45) | LMNAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL19381479 | 0.78 | LMNA (0.45) | LMNAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3098091 | 0.76 | LMNA (0.43) | LMNAKDM4EADRA2AADRA2CHIF1A | |
| SCHEMBL2238856 | 0.75 | ALDH1A1 (0.50) | LMNAALDH1A1CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL13339074 | 0.75 | ALDH1A1 (0.50) | LMNAALDH1A1CYP2D6CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250156-A1 | PYRAZINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES | Merck Patent GmbH (DE) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009109259-A1 | PYRAZINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2009-09-11 | — | — | WO | disclosed |