Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 9/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401052 | 0.83 | CYP2C9 (0.65) | CYP2C9CYP2C19MAPK14MEN1KMT2A | |
| SCHEMBL3401392 | 0.78 | KMT2A (0.44) | MEN1KMT2ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7234983 | 0.74 | CYP2C9 (1.00) | CYP2C9CYP2C19MAPK14MEN1KMT2A | |
| SCHEMBL7604997 | 0.74 | CYP2C9 (0.77) | CYP2C9CYP2C19MAPK14MEN1KMT2A | |
| SCHEMBL5823073 | 0.74 | CYP2C9 (0.77) | CYP2C9CYP2C19MAPK14MEN1KMT2A | |
| SCHEMBL7231606 | 0.73 | CYP2C9 (0.69) | CYP2C9CYP2C19MAPK14MEN1KMT2A | |
| SCHEMBL7239766 | 0.73 | CYP2C9 (0.65) | CYP2C9CYP2C19MAPK14MEN1KMT2A | |
| SCHEMBL5820252 | 0.72 | CYP2C9 (0.77) | CYP2C9CYP2C19MAPK14MEN1KMT2A | |
| SCHEMBL7244230 | 0.72 | MEN1 (0.69) | CYP2C9CYP2C19MAPK14MEN1KMT2A | |
| SCHEMBL7239929 | 0.71 | MGLL (0.66) | CYP2C9CYP2C19MAPK14MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247588-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009107850-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-03 | — | — | WO | disclosed |