Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400976 | 0.81 | KMT2A (0.50) | KMT2AALDH1A1SMN1; SMN2MEN1HPGD | |
| SCHEMBL16233183 | 0.71 | ALDH1A1 (0.54) | KMT2AALDH1A1SMN1; SMN2MEN1HPGD | |
| SCHEMBL10447618 | 0.69 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2KDM4EGAAL3MBTL1 | |
| SCHEMBL3400265 | 0.66 | HTR2C (0.46) | KMT2AALDH1A1SMN1; SMN2MEN1HPGD | |
| SCHEMBL7879085 | 0.66 | ALDH1A1 (0.53) | KMT2AALDH1A1SMN1; SMN2MEN1HPGD | |
| SCHEMBL8322979 | 0.66 | DRD2 (0.70) | ALDH1A1HPGDKDM4EL3MBTL1DRD2 | |
| SCHEMBL15649918 | 0.65 | ALDH1A1 (0.57) | KMT2AALDH1A1SMN1; SMN2MEN1HPGD | |
| SCHEMBL22172135 | 0.65 | ALDH1A1 (0.52) | KMT2AALDH1A1MEN1HPGDKDM4E | |
| SCHEMBL4283460 | 0.64 | ALDH1A1 (0.58) | KMT2AALDH1A1SMN1; SMN2MEN1KDM4E | |
| SCHEMBL10282569 | 0.64 | MEN1 (0.70) | KMT2AALDH1A1SMN1; SMN2MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247588-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009107850-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-03 | — | — | WO | disclosed |