Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 8/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | GRM5 | P41594 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.49 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402699 | 0.85 | TP53 (0.57) | METTP53MAPTGRM5SMURF1 | |
| SCHEMBL7995426 | 0.84 | RIPK1 (0.50) | METTP53MAPTGRM5SORT1 | |
| SCHEMBL3402413 | 0.84 | TP53 (0.50) | METTP53MAPTGRM5SMURF1 | |
| SCHEMBL3404285 | 0.83 | MET (0.63) | METPOLBTP53MAPTGRM5 | |
| SCHEMBL3401287 | 0.83 | MET (0.63) | METPOLBTP53MAPTGRM5 | |
| SCHEMBL3407140 | 0.78 | MAPT (0.60) | METPOLBTP53MAPTGRM5 | |
| SCHEMBL3400866 | 0.78 | MAPT (0.58) | METPOLBTP53MAPTGRM5 | |
| SCHEMBL3433965 | 0.73 | TP53 (0.55) | METTP53MAPTGRM5SMURF1 | |
| SCHEMBL3404139 | 0.73 | MET (0.61) | METTP53MAPTGRM5SMN1; SMN2 | |
| SCHEMBL3406655 | 0.72 | POLB (0.62) | METPOLBTP53MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252599-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | Glaxo Group Limited (GB) | 2010-11-24 | — | — | EP | claimed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | claimed |
| EP-2252599-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | Glaxo Group Limited (GB) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |