Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.63 |
| ▸ | GRM5 | P41594 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404285 | 0.92 | MET (0.63) | METGRM5POLBTP53MAPT | |
| SCHEMBL3407140 | 0.85 | MAPT (0.60) | METGRM5POLBTP53MAPT | |
| SCHEMBL3400866 | 0.84 | MAPT (0.58) | METGRM5POLBTP53MAPT | |
| SCHEMBL3401246 | 0.83 | MET (0.56) | METGRM5POLBTP53MAPT | |
| SCHEMBL3404139 | 0.82 | MET (0.61) | METGRM5TP53MAPTSMN1; SMN2 | |
| SCHEMBL3405011 | 0.78 | MET (0.59) | METGRM5TP53MAPTSMN1; SMN2 | |
| SCHEMBL3407265 | 0.74 | MAPT (0.65) | METTP53MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3403988 | 0.74 | SMN1; SMN2 (0.64) | POLBTP53MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8001635 | 0.73 | MAPT (0.58) | METTP53MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7986940 | 0.73 | MAPT (0.55) | METGRM5POLBTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252599-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | Glaxo Group Limited (GB) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |