Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMYD2 | Q9NRG4 | 5/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ULK1 | O75385 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404848 | 0.97 | RAB9A (0.45) | RAB9AGAASMYD2MKNK2MAPT | |
| SCHEMBL3396887 | 0.94 | RAB9A (0.48) | RAB9AGAASMYD2MKNK2MAPT | |
| SCHEMBL3405409 | 0.94 | SCN9A (0.47) | RAB9ASTAT3 | |
| SCHEMBL3401224 | 0.93 | SCN9A (0.49) | RAB9AGAASTAT3 | |
| SCHEMBL3401313 | 0.88 | SCN9A (0.47) | STAT3 | |
| SCHEMBL3400482 | 0.88 | DRD2 (0.46) | GAASMYD2MAPTKMT2A | |
| SCHEMBL3405360 | 0.87 | SCN9A (0.49) | GAASTAT3 | |
| SCHEMBL3402323 | 0.85 | DPP4 (0.49) | GAA | |
| SCHEMBL3402585 | 0.84 | DRD2 (0.47) | SMYD2MKNK2 | |
| SCHEMBL3402094 | 0.84 | DPP4 (0.50) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |