Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401224 | 0.99 | SCN9A (0.49) | SCN9ATSHRSRCCACNA1GNPSR1 | |
| SCHEMBL3401280 | 0.94 | RAB9A (0.48) | RAB9ASTAT3 | |
| SCHEMBL3401313 | 0.94 | SCN9A (0.47) | SCN9ATSHRSRCCACNA1GNPSR1 | |
| SCHEMBL3404848 | 0.93 | RAB9A (0.45) | SCN9ARAB9ASTAT3 | |
| SCHEMBL3405360 | 0.93 | SCN9A (0.49) | SCN9ATSHRSRCCACNA1GNPSR1 | |
| SCHEMBL3402323 | 0.90 | DPP4 (0.49) | SCN9ACACNA1GNPSR1CHRM4 | |
| SCHEMBL3402094 | 0.89 | DPP4 (0.50) | SCN9ACACNA1GCHRM4 | |
| SCHEMBL3396887 | 0.88 | RAB9A (0.48) | RAB9APDGFRBKDRSTAT3 | |
| SCHEMBL3403561 | 0.84 | WNT1 (0.52) | SCN9ATSHRNPSR1CHRM4PARP1 | |
| SCHEMBL13309881 | 0.84 | ACKR3 (0.54) | CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |